Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes
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چکیده
منابع مشابه
Molecular characterization and analysis of the porcine betaine homocysteine methyltransferase and betaine homocysteine methyltransferase-2 genes.
Betaine homocysteine methyltransferase (BHMT) and BHMT-2 enzymes methylate homocysteine to form methionine using betaine and S-methylmethionine, respectively. These activities are observed only in the liver of adult rodents, but in adult humans and pigs these activities are detected in both the liver and kidney, indicating the pig is a more appropriate model for studying the biochemical and phy...
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Disorder in re-methylation process of homocysteine to methionine due to mutation in betaine homocysteine methyltransferase enzyme (BHMT) coding gene, leads to decrease in S-adenosyl methionine (SAM) synthesis which takes part in DNA methylation as a methyl donor. As a result, it can promote hypo-methylation of DNA, chromosome instability, and chromosome missegregation, which in turn is one of t...
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Betaine-homocysteine S-methyltransferase (BHMT) and BHMT2 convert homocysteine to methionine using betaine and S-methylmethionine, respectively, as methyl donor substrates. Increased levels of homocysteine in blood are associated with cardiovascular disease. Given their role in human health and nutrition, we identified BHMT and BHMT2 genes and proteins from 38 species of deuterostomes including...
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ژورنال
عنوان ژورنال: Gene
سال: 2011
ISSN: 0378-1119
DOI: 10.1016/j.gene.2010.11.015